Let's say you have your 11 sets in A3:F13 with the megaball in column F.
List the winning numbers in A1:F1 then select the range A3:E13 and use conditional formatting with this formula
=MATCH(A3,$A$1:$E$1,0)
format as required
Then select F3:F13 and use the formula
=F3=$F$1
and also format as required
That will highlight all matching numbers
You could also use a worksheet formula, e.g. in G3 copied down that would tell you how many matches you have, i.e.
=SUMPRODUCT(--ISNUMBER(MATCH(A3:E3,A$1:E$1,0)))&" + "&(F3=F$1)+0