Well --- depends on the query, but the more complex you make the data source, the harder it will be to add records using it, especially if a many-to-many relationship is involved. The reason is that Access needs to increment the Primary Key when you add a record. If there are multiple keys, it often refuses to do it.
However -- big, multi-table queries are GREAT for reports. You can get all the data you need in a useful layout.
As cstlaurent said, keep it simple for data entry. Base your data entry forms on simple tables or simple queries, and use combos to pull external ID fields into your data table.
Denis