'To find the last row of data in column A of Sheet2, use:
LastRow = Sheets("Sheet2").Range("A65536").End(xlUp).Row
'If you're using Excel 2007, change the 65536 to 1048576.
'To copy 5 columns of data from Sheet1 to Sheet2 assuming the source row on Sheet1 is 12:
For ColNo = 1 to 5
Sheets("Sheet2").Cells(LastRow + 1, ColNo) = Sheets("Sheet1").Cells(12, ColNo)
Next ColNo
There might be more efficient ways to accomplish this, but that's my 2 cents.