When you say "delete", I assume you mean physically delete the columns themselves and not simply clear the cell values within the columns. Give this macro a try...
Code:
Sub ColumnsDeleter()
Range(ActiveCell.Offset(, 1), Columns(Columns.Count)).EntireColumn.Delete
If ActiveCell.Column > 2 Then Range("B1", ActiveCell.Offset(, -1)).EntireColumn.Delete
End Sub
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