If you mean that you don't want A:X to ever change widths, you can do that with VBA. You'd have to note the current widths, and upon worksheet change, reset the widths to those. For example, if you want the widths to always be 8.1, you can do this -- right-click the sheet tab, select View Code, enter this:
Private Sub Worksheet_Change(ByVal Target As Range)
Range("A:X").ColumnWidth = 8.1
End Sub
If the widths are varying, let me know and I'll give the more involved answer.