Yes, it is. You could put something like this into your ThisWorkbook module ...
<font face=Tahoma New><SPAN style="color:#00007F">Private</SPAN> <SPAN style="color:#00007F">Sub</SPAN> Workbook_BeforeSave(<SPAN style="color:#00007F">ByVal</SPAN> SaveAsUI <SPAN style="color:#00007F">As</SPAN> <SPAN style="color:#00007F">Boolean</SPAN>, Cancel As <SPAN style="color:#00007F">Boolean</SPAN>)
<SPAN style="color:#00007F">With</SPAN> Sheets("Sheet1").Range("A1")
.Value = .Value + 1
<SPAN style="color:#00007F">End</SPAN> <SPAN style="color:#00007F">With</SPAN>
<SPAN style="color:#00007F">End</SPAN> <SPAN style="color:#00007F">Sub</SPAN>
<SPAN style="color:#00007F">Private</SPAN> <SPAN style="color:#00007F">Sub</SPAN> Workbook_Open()
<SPAN style="color:#00007F">With</SPAN> Sheets("Sheet1").Range("A1")
.Value = .Value + 1
<SPAN style="color:#00007F">End</SPAN> <SPAN style="color:#00007F">With</SPAN>
<SPAN style="color:#00007F">End</SPAN> <SPAN style="color:#00007F">Sub</SPAN></FONT>
HTH