To average the last 4 cells in Column A, try the following...
Insert > Name > Define
Name: BigNum
Refers to:
=9.99999999999999E+307
Click Ok
Then try the following...
=AVERAGE(INDEX(A2:A65536,MATCH(BigNum,A2:A65536)-3):INDEX(A2:A65536,MATCH(BigNum,A2:A65536)))
Hope this helps!