Saving only certain columns

[ScotTFO]

I am wondering what the best process of this would be.

I have a document that calls an assortment of functions and populates more than half the cells with data pulled from remote sources and such, then compares it to values in the current document.

Ok I hope I explained that well.

Some of the columns have data the user may have to change, now I want to find a way so that when they save the document, it only saves the values from those columns that I select and not the other that only have data after the process is ran.

Let me know if I need to clear anything else up so it's more understandable

Thanks!