Multiple columns of data, want unique combinations

Coydog

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I have multiple columns of data and want to create a unique combination of each column's data going down in rows. any thoughts?
 

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I have multiple columns of data and want to create a unique combination of each column's data going down in rows. any thoughts?

Maybe you could concatenate all of the target columns together in a helper column and then use advanced filter (unique) on the helper column.
 
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